PREDICTORS FOR PROGNOSIS OF CHRONIC MYELOCYTIC-LEUKEMIA

被引：0
作者：
CHEN, SS
ZHANG, HF
XUE, WT
LI, K
WANG, P
LUI, Y
机构：
来源：
CHINESE MEDICAL JOURNAL | 1993年 / 106卷 / 10期
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D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bone marrows from 30 newly disposed Ph+chronic myelocytic leukemia (CML) (21 in chronic phase, CML-CP, 9 in accelerate phase,CML-AP) and 8 followed up patients in blast crisis (CML-BC) were tested by DNA strand breaks (%D value), DNA-aneuploidy, flow cytometry-cell surface antigen expression for CD15 and HLA-DR ratio. Our results showed that all these three parameters changed as the disease escalated. A very low value of %D and DNA-aneuploidy occurrences were high risk factors. Cell surface antigen expression CD15 and HLA-DR ratio measurement was simple and reliable. The ratio < 1.0 appeared earlier than morphology clarifying CML-AP and should be followed up regularly.
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页码：760 / 762
页数：3
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