ULTRASTRUCTURAL-CHANGES IN THE MICROVILLI AS A MARKER OF SMALL-BOWEL REJECTION

被引：2

作者：

YAMATAKA, A

MIYANO, T

KATO, Y

NOZAWA, M

SASAKI, K

机构：

[1] The Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, 113, 2-1-1 Hongo, Bunkyo-ku

[2] The Department of Surgery, Meikai University, Saiama, 1-1 Keyakidai, Sakado

[3] The Department of Anatomy, Yokohama City University School of Medicine, Yokohama, 236, 3-9 Fukuura, Kanazawa-ku

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1993年 / 23卷 / 11期

关键词：

SMALL BOWEL TRANSPLANTATION; REJECTION;

D O I：

10.1007/BF00308974

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Small bowel rejection occurs in patches; therefore, to detect bowel rejection in situations where a stomal biopsy appears normal under the light microscope, we studied the ultrastructural changes in bowel microvilli following heterotopic small bowel transplantation in rats. Thin sections of bowel biopsy specimens, which appeared normal under a light microscope, were selected and examined under an electron microscope for microvillous changes. Microvillous changes were seen in both the syngeneic and allogeneic groups on the 2nd and 4th postoperative days, but these changes were absent in the syngeneic group by the 8th postoperative day, although they were still detected in the allogeneic group. Thus, following small bowel transplantation, electron microscopic analysis is recommended to confirm rejection with a patchy distribution after the 8th postoperative day.

引用

页码：984 / 987

页数：4

共 12 条

[1]

Cohen Z., Nordgren S., Lossing A., Morphological studies of intestinal allograft rejection, Dis Colon Rectum, 27, pp. 228-234, (1984)

[2]

Lossing A., Nordgren S., Cohen Z., Histological monitoring of rejection in small intestinal transplantation, Transplant Proc, 14, pp. 643-645, (1982)

[3]

Yamataka A., Miyano T., Fukunaga K., Kobayashi H., Nozawa M., Sasaki K., Patchy distribution of rejection changes in small bowel intestinal transplantation, J Pediatr Surg, 27, pp. 602-603, (1992)

[4]

Grant D., Intestinal transplantation: Current status, Transplant Proc, 21, pp. 2869-2871, (1989)

[5]

Grant D., Wall W., Zhong R., Mimeault R., Sutherland F., Ghent C., Duff J., Experimental clinical intestinal transplantation: Initial experience of a Canadian centre, Transplant Proc, 22, pp. 2497-2498, (1990)

[6]

Nordgren S., Cohen Z., MacKenzie R., Functional monitors of rejection in small intestinal transplants, Am J Surg, 147, pp. 152-158, (1984)

[7]

Billiar T.R., Garberoglio C., Schraut W.H., Maltose absorption as an indicator of small-intestinal allograft rejection, J Surg Res, 37, pp. 75-82, (1984)

[8]

Teitelbaum D.H., Dunaway D.J., Sonnino R.E., Stellin G., Berend M.E., Harmel R.P., Leakage of intraluminal low molecular weight polyethylene glycol as a marker of small bowel transplant rejection, J Pediatr Surg, 24, pp. 64-69, (1989)

[9]

Lee M.D., Smith S.D., Yunis E.J., Rowe M.I., In vivo transmural potential difference: An early monitor of rejection in small bowel transplantation, J Pediatr Surg, 24, pp. 767-770, (1989)

[10]

Ganong W.F., Gastrointestinal function, Review of medical physiology, pp. 391-428, (1987)

← 1 2 →