INHIBITORY EFFECT OF IDAZOXAN ON FORSKOLIN-STIMULATED ADENYLATE-CYCLASE ACTIVITY THROUGH 5-HYDROXYTRYPTAMINE(1A) RECEPTORS

被引：0

作者：

KAWAI, N

YAMAMOTO, T

BABA, A

YAMAMOTO, H

MOROJI, T

机构：

[1] TOKYO INST PSYCHIAT,DEPT PSYCHOPHARMACOL,SETAGAYA KU,TOKYO,TOKYO 156,JAPAN

[2] UNIV TSUKUBA HOSP,PSYCHIAT SERV,TSUKUBA,IBARAKI,JAPAN

[3] YOKOHAMA CITY UNIV,GRAD SCH INTEGRATED SCI,MOLEC RECOGNIT LAB,YOKOHAMA,KANAGAWA,JAPAN

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1994年 / 44-1卷 / 01期

关键词：

ADENYLATE CYCLASE; CAS; 79944562; 5-HYDROXYTRYPTAMINE(1A) RECEPTOR; IDAZOXAN; RECEPTOR BINDING STUDIES;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The binding affinity of the alpha(2)-adrenoceptor antagonist idazoxan (CAS 79944-56-2) to 5-hydroxytryptamine(1A) (5-HT1A) receptors and its effect on the forskolin-stimulated adenylate cyclase activity in the rat hippocampus were examined. Idazoxan had moderate affinity for the 5-HT1A receptors. It inhibited the forskolin-stimulated adenylate cyclase activity, to the same extent as 5-HT. The 5-HT1A receptor antagonist spiperone shifted the concentration-response curve of idazoxan to the right in a parallel manner. These results indicate that idazoxan is a 5-HT1A agonist.

引用

页码：1 / 3

页数：3

共 11 条

[1] SIMPLE AND SENSITIVE SATURATION ASSAY METHOD FOR MEASUREMENT OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE [J].