Asthma-COPD overlap syndrome

被引:2
作者
Sen, Elif [1 ]
Oguzulgen, Kivilcim [2 ]
Bavbek, Sevim [3 ]
Gunen, Hakan [4 ]
Kiyan, Esen [5 ]
Turktas, Haluk [2 ]
Yorgancioglu, Arzu [6 ]
Polatli, Mehmet [7 ]
Yildiz, Fusun [8 ]
Celik, Gulfem [3 ]
Demir, Tuncalp [9 ]
Gemicioglu, Bilun [9 ]
Mungan, Dilsad [3 ]
Saryal, Sevgi [1 ]
Sayiner, Abdullah [10 ]
Yildirim, Nurhayat [9 ]
机构
[1] Ankara Univ, Fac Med, Dept Chest Dis, Ankara, Turkey
[2] Gazi Univ, Fac Med, Dept Chest Dis, Ankara, Turkey
[3] Ankara Univ, Fac Med, Div Immunol & Allergy, Ankara, Turkey
[4] Sureyyapasa Chest Dis & Chest Surg Training & Res, Clin Chest Dis, Istanbul, Turkey
[5] Istanbul Univ, Istanbul Fac Med, Dept Chest Dis, Istanbul, Turkey
[6] Celal Bayar Univ, Fac Med, Dept Chest Dis, Manisa, Turkey
[7] Adnan Menderes Univ, Fac Med, Dept Chest Dis, Aydin, Turkey
[8] Kocaeli Univ, Fac Med, Dept Chest Dis, Kocaeli, Turkey
[9] Istanbul Univ, Fac Cerrahpasa Med, Dept Chest Dis, Istanbul, Turkey
[10] Ege Univ, Fac Med, Dept Chest Dis, Izmir, Turkey
来源
TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX | 2015年 / 63卷 / 04期
关键词
Asthma-COPD overlap syndrome; diagnosis; guidelines; treatment;
D O I
10.5578/tt.9885
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Asthma and chronic obstructive pulmonary disease (COPD) are common lung diseases characterized by chronic airway inflammation and airway obstruction. Among patient with COPD and asthma; there is a group of patients with an overlap between clinical, functional characteristics and airway inflammation patterns, named "Asthma-COPD Overlap Syndrome" (ACOS). ACOS is a syndrome characterized by reversible but persistant airflow limitation (postbronchodilator FEV1/FVC < 70%) which has some features of both asthma and COPD. ACOS should be suspected in a patient > 40 years, with smoking history, previous asthma diagnosis or history of childhood asthma who has persistant airflow limitation and reversible ariway obstruction (defined by an increase of > % 12 of FEV1 pred or increase of FEV1 > 200 mL after inhalation of 400 mcg salbutamol or 1000 mcg terbutaline). The prevalence for ACOS has been reported 11-55% in different case series to date and increases by age and is more frequent in females in different age groups. Patients with ACOS are younger than COPD patients and older than asthma patients. Frequent and severe exacerbations and related hospitalization and emergency room visits are common in ACOS and this causes an impaired quality of life. Current recommendations of guidelines for pharmacologic treatment of ACOS have been composed of a combination with optimal COPD and asthma treatment. Future therapeutic approaches should be based on endotypes. Clinical phenotype and underlying endotype driven clinical studies may be the base of ACOS guidelines.
引用
收藏
页码:265 / 277
页数:13
相关论文
共 61 条
  • [1] Agusti Alvar, 2013, Ann Am Thorac Soc, V10 Suppl, pS125, DOI 10.1513/AnnalsATS.201303-055AW
  • [2] Non-atopic males with adult onset asthma are at risk of persistent airflow limitation
    Amelink, M.
    de Nijs, S. B.
    Berger, M.
    Weersink, E. J.
    ten Brinke, A.
    Sterk, P. J.
    Bel, E. H.
    [J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2012, 42 (05) : 769 - 774
  • [3] Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
    Anderson, Gary P.
    [J]. LANCET, 2008, 372 (9643) : 1107 - 1119
  • [4] Severe exacerbations predict excess lung function decline in asthma
    Bai, T. R.
    Vonk, J. M.
    Postma, D. S.
    Boezen, H. M.
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2007, 30 (03) : 452 - 456
  • [5] Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA Cohort Study
    Brutsche, M. H.
    Downs, S. H.
    Schindler, C.
    Gerbase, M. W.
    Schwartz, J.
    Frey, M.
    Russi, E. W.
    Ackermann-Liebrich, U.
    Leuenberger, P.
    [J]. THORAX, 2006, 61 (08) : 671 - 677
  • [6] The Asthma COPD Overlap Syndrome (ACOS)
    Bujarski, Stephen
    Parulekar, Amit D.
    Sharafkhaneh, Amir
    Hanania, Nicola A.
    [J]. CURRENT ALLERGY AND ASTHMA REPORTS, 2015, 15 (03)
  • [7] Parameters associated with persistent airflow obstruction in chronic severe asthma
    Bumbacea, D
    Campbell, D
    Nguyen, L
    Carr, D
    Barnes, PJ
    Robinson, D
    Chung, KF
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2004, 24 (01) : 122 - 128
  • [8] Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma
    Chalmers, GW
    Macleod, KJ
    Little, SA
    Thomson, LJ
    McSharry, CP
    Thomson, NC
    [J]. THORAX, 2002, 57 (03) : 226 - 230
  • [9] Corticosteroid reversibility in COPD is related to features of asthma
    Chanez, P
    Vignola, AM
    OShaugnessy, T
    Enander, I
    Li, DC
    Jeffery, PK
    Bousquet, J
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 155 (05) : 1529 - 1534
  • [10] Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma
    Chaudhuri, R
    Livingston, E
    McMahon, AD
    Thomson, L
    Borland, W
    Thomson, NC
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 168 (11) : 1308 - 1311