THE EFFECTS OF GAMMA-LINOLENIC ACID ON BREAST PAIN AND DIABETIC NEUROPATHY - POSSIBLE NONEICOSANOID MECHANISMS

被引:16
作者
HORROBIN, DF
机构
[1] Efamol Research Institute, Kentville, NS B4N 4H8
来源
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1993年 / 48卷 / 01期
关键词
D O I
10.1016/0952-3278(93)90016-P
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Gamma-linolenic acid (GLA) has recently been found to be beneficial in the management of breast pain and of diabetic neuropathy. GLA is a precursor of unsaturated fatty acids which are important in membrane structures, as second messengers in their own right and as precursors of eicosanoids. While the mechanisms of GLA action are likely to be complex, non-eicosanoid effects are probably of substantial importance. These effects include modification of membrane fluidity and of the functions of lipid-associated receptors and changes in the inositol cycle.
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收藏
页码:101 / 104
页数:4
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