IS INTERLEUKIN-2 A NEUROMODULATOR IN THE BRAIN

被引：107

作者：

NISTICO, G ^{[1
]}

DESARRO, G ^{[1
]}

机构：

[1] UNIV CATANZARO POLICLIN,FAC MED,INST PHARMACOL,I-88100 CATANZARO,ITALY

来源：

TRENDS IN NEUROSCIENCES | 1991年 / 14卷 / 04期

关键词：

D O I：

10.1016/0166-2236(91)90086-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A bidirectional flow of information exists between the CNS and the neuroendocrine and immune systems, representing an important homeostatic mechanism in the body. Lymphokines and other products of immunocompetent cells seem to play a crucial role in this communication and seem to exert powerful effects on neurones in the brain. In this article, Giuseppe Nistico and Giovambattista De Sarro describe the central effects following interleukin 2 (IL-2) microinfusion into several areas of the rat brain. The locus coeruleus seems to be the main site in the brain through which IL-2 exerts soporific effects. In addition, the possible transducing mechanisms coupling IL-2 receptor stimulation and the electroencephalogram (EEG) spectrum power responses elicited from the locus coeruleus seem to involve stimulation of specific receptors coupled to adenylate cyclase through a G(i) protein.

引用

页码：146 / 150

页数：5

共 55 条

[1]

ARANJO DM, 1989, BRAIN RES, V498, P257

[2] BIDIRECTIONAL TRANSPORT OF INTERLEUKIN-1-ALPHA ACROSS THE BLOOD-BRAIN-BARRIER [J].

BANKS, WA ;

KASTIN, AJ ;

DURHAM, DA .

BRAIN RESEARCH BULLETIN, 1989, 23 (06) :433-437

[3]

BECKNER SK, 1986, J BIOL CHEM, V261, P3043

[4]

BECKNER SK, 1988, J IMMUNOL, V140, P208

[5] STIMULATION OF OLIGODENDROGLIAL PROLIFERATION AND MATURATION BY INTERLEUKIN-2 [J].

BENVENISTE, EN ;

MERRILL, JE .

NATURE, 1986, 321 (6070) :610-613

[6] HYPOTHALAMIC CHANGES DURING IMMUNE-RESPONSE [J].

BESEDOVSKY, H ;

SORKIN, E ;

FELIX, D ;

HAAS, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1977, 7 (05) :323-325

[7] INTERLEUKIN-2 MODIFIES THE BIOELECTRIC ACTIVITY OF SOME NEUROSECRETORY NUCLEI IN THE RAT HYPOTHALAMUS [J].

BINDONI, M ;

PERCIAVALLE, V ;

BERRETTA, S ;

BELLUARDO, N ;

DIAMANTSTEIN, T .

BRAIN RESEARCH, 1988, 462 (01) :10-14

[8] INTERLEUKIN-2 AND GTP BINDING IN LYMPHOCYTES [J].

BOURNE, HR .

NATURE, 1987, 326 (6116) :833-834

[9] INTERLEUKIN-1 IMMUNOREACTIVE INNERVATION OF THE HUMAN HYPOTHALAMUS [J].

BREDER, CD ;

DINARELLO, CA ;

SAPER, CB .

SCIENCE, 1988, 240 (4850) :321-324

[10] MECHANISM OF CHOLERA TOXIN ACTION - COVALENT MODIFICATION OF GUANYL NUCLEOTIDE-BINDING PROTEIN OF ADENYLATE-CYCLASE SYSTEM [J].

CASSEL, D ;

PFEUFFER, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (06) :2669-2673

← 1 2 3 4 5 6 →