Pulmonary alveolar proteinosis due to mycophenolate and cyclosporine combination therapy in a renal transplant recipient

被引：10

作者：

Hasan, Ashfaq ^{[1
,3
]}

Ram, Raja ^{[2
]}

Swamy, T. L. N. ^{[3
]}

机构：

[1] Owaisi Hosp & Res Ctr, Dept Pulm Med, Hyderabad, Telangana, India

[2] Owaisi Hosp & Res Ctr, Dept Nephrol, Hyderabad, Telangana, India

[3] Care Hosp, Dept Pulmonol, Hyderabad, Telangana, India

来源：

LUNG INDIA | 2014年 / 31卷 / 03期

关键词：

Alveolar proteinosis; cyclosporin; mycophenolate; renal transplant; immunosuppression;

D O I：

10.4103/0970-2113.135782

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Pulmonary alveolar proteinosis (PAP) is an orphan disease characterized by the accumulation of excess of surfactant within alveoli and bronchioles. The primary form of PAP (P-PAP: also referred to as idiopathic or autoimmune) is the most common form. It is mediated through a circulating neutralizing antibody against granulocyte-macrophage colony-stimulating factor. Secondary PAP (S-PAP) can be induced by a host of inciting agents and is far more liable to progress to terminal respiratory failure. We describe a rare case of S-PAP occurring in a renal transplant recipient due to mycophenolate and cyclosporine combination-therapy, which resolved spontaneously following withdrawal of these drugs.

引用

页码：282 / 284

页数：3

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