THE SERUM CONCENTRATION OF ACTIVE TRANSFORMING GROWTH-FACTOR-BETA IS SEVERELY DEPRESSED IN ADVANCED ATHEROSCLEROSIS

被引：363
作者：
GRAINGER, DJ
KEMP, BR
METCALFE, JC
LIU, AC
LAWN, RM
WILLIAMS, NR
GRACE, AA
SCHOFIELD, PM
CHAUHAN, A
机构：
[1] STANFORD UNIV, SCH MED, FALK CARDIOVASC RES CTR, STANFORD, CA 94305 USA
[2] PAPWORTH HOSP NHS TRUST, DEPT CARDIOL, CAMBRIDGE CB3 8RE, ENGLAND
来源：
NATURE MEDICINE | 1995年 / 1卷 / 01期
关键词：
D O I：
10.1038/nm0195-74
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent evidence has led us to propose that transforming growth factor-beta (TGF-beta) is a key inhibitor of atherosclerosis. We show here that a population of patients with advanced atherosclerosis all have less active TGF-beta in their sera than patients with normal coronary arteries, with a fivefold difference in average concentration between the two groups. This correlation with atherosclerosis is much stronger than for other known major risk factors and it may therefore have important diagnostic and prognostic significance. Aspirin medication correlates with an increase in active TGF-beta concentration, indicating that therapeutic interventions for TGF-beta are possible.
引用
收藏
页码：74 / 79
页数：6
相关论文
共 26 条
[1]  
BUTTA A, 1992, CANCER RES, V52, P4261
[2]   ANTIESTROGENS INDUCE THE SECRETION OF ACTIVE TRANSFORMING GROWTH-FACTOR-BETA FROM HUMAN FETAL FIBROBLASTS [J].
COLLETTA, AA ;
WAKEFIELD, LM ;
HOWELL, FV ;
VANROOZENDAAL, KEP ;
DANIELPOUR, D ;
EBBS, SR ;
SPORN, MB ;
BAUM, M .
BRITISH JOURNAL OF CANCER, 1990, 62 (03) :405-409
[3]  
DEBONO D, 1994, BRIT HEART J, V71, P504
[4]   FAMILIAL LIPOPROTEIN DISORDERS IN PATIENTS WITH PREMATURE CORONARY-ARTERY DISEASE [J].
GENEST, JJ ;
MARTINMUNLEY, SS ;
MCNAMARA, JR ;
ORDOVAS, JM ;
JENNER, J ;
MYERS, RH ;
SILBERMAN, SR ;
WILSON, PWF ;
SALEM, DN ;
SCHAEFER, EJ .
CIRCULATION, 1992, 85 (06) :2025-2033
[5]  
GORDON DJ, 1989, NEW ENGL J MED, V321, P1311
[6]  
GRAINGER D, IN PRESS CLIN CHIM A
[7]   TAMOXIFEN DECREASES THE RATE OF PROLIFERATION OF RAT VASCULAR SMOOTH-MUSCLE CELLS IN CULTURE BY INDUCING PRODUCTION OF TRANSFORMING GROWTH-FACTOR-BETA [J].
GRAINGER, DJ ;
WEISSBERG, PL ;
METCALFE, JC .
BIOCHEMICAL JOURNAL, 1993, 294 :109-112
[8]   ACTIVATION OF TRANSFORMING GROWTH-FACTOR-BETA IS INHIBITED IN TRANSGENIC APOLIPOPROTEIN(A) MICE [J].
GRAINGER, DJ ;
KEMP, PR ;
LIU, AC ;
LAWN, RM ;
METCALFE, JC .
NATURE, 1994, 370 (6489) :460-462
[9]   PROLIFERATION OF HUMAN SMOOTH-MUSCLE CELLS PROMOTED BY LIPOPROTEIN(A) [J].
GRAINGER, DJ ;
KIRSCHENLOHR, HL ;
METCALFE, JC ;
WEISSBERG, PL ;
WADE, DP ;
LAWN, RM .
SCIENCE, 1993, 260 (5114) :1655-1658
[10]   INCREASED PLASMA-LEVELS OF A RAPID INHIBITOR OF TISSUE PLASMINOGEN-ACTIVATOR IN YOUNG SURVIVORS OF MYOCARDIAL-INFARCTION [J].
HAMSTEN, A ;
WIMAN, B ;
DEFAIRE, U ;
BLOMBACK, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (25) :1557-1563
123