TIME-DEPENDENT PERCUTANEOUS-ABSORPTION ENHANCING EFFECT OF ETHANOL

被引：18

作者：

HATANAKA, T ^{[1
]}

KATAYAMA, K ^{[1
]}

KOIZUMI, T ^{[1
]}

SUGIBAYASHI, K ^{[1
]}

MORIMOTO, Y ^{[1
]}

机构：

[1] JOSAI UNIV,FAC PHARMACEUT SCI,SAKADO,SAITAMA 35002,JAPAN

来源：

JOURNAL OF CONTROLLED RELEASE | 1995年 / 33卷 / 03期

关键词：

ETHANOL; PERCUTANEOUS ABSORPTION ENHANCER; TIME DEPENDENCE; DELIPIDIZATION;

D O I：

10.1016/0168-3659(94)00120-J

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The time dependence of the skin permeation enhancing effect of ethanol was investigated quantitatively. Ethanol enhanced the skin permeability of drugs in a manner dependent on the polarity of drugs and pretreatment time with ethanol. The skin permeation data were analyzed based on the parallel permeation pathway model, and the change in several permeation parameters by ethanol pretreatment was estimated. Further, the change was related mathematically with the delipidizing effect of ethanol on the skin, which is an index of ethanol concentration in the stratum corneum. The time-dependent percutaneous absorption enhancing effect of ethanol could be described by the change of permeation parameters dependent on ethanol concentration in the stratum corneum.

引用

页码：423 / 428

页数：6

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