AIRWAYS REMODELING IN ASTHMA - NO DOUBT, NO MORE

被引：64

作者：

BOUSQUET, J

VIGNOLA, AM

CHANEZ, P

CAMPBELL, AM

BONSIGNORE, G

MICHEL, FB

机构：

[1] CHU MONTPELLIER,MALAD RESP CLIN,MONTPELLIER,FRANCE

[2] CHU MONTPELLIER,INSERM,CJF 9210,MONTPELLIER,FRANCE

[3] IST FISIOPATOL RESP,PALERMO,ITALY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

ASTHMA; AIRWAY REMODELING; TGF-BETA; EGF; AIRWAY INFLAMMATION;

D O I：

10.1159/000236980

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma is a chronic inflammatory disease of the airways invariably associated with healing. Remodelling of the airways can be demonstrated by the activation of airways macrophages, the release of growth factors and fibrogenic cytokines, the activation of fibroblasts and myofibroblast, elastolysis and elastosynthesis, collagen deposition, increased synthesis and release of extracellular matrix components, and an increased mass of smooth muscle and mucous glands. However, the control of remodelling is still poorly understood.

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页码：211 / 214

页数：4

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