USING PURIFIED P-GLYCOPROTEIN TO UNDERSTAND MULTIDRUG-RESISTANCE

被引：66
作者：
SHAPIRO, AB
LING, V
机构：
[1] ONTARIO CANC INST,DIV MOLEC & STRUCT BIOL,TORONTO,ON M4X 1K9,CANADA
[2] UNIV TORONTO,DEPT MED BIOPHYS,TORONTO,ON M4X 1K9,CANADA
来源：
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1995年 / 27卷 / 01期
关键词：
P-GLYCOPROTEIN; MULTIDRUG RESISTANCE;
D O I：
10.1007/BF02110325
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Since P-glycoprotein was discovered almost 20 years ago, its causative role in multidrug resistance has been established, but central problems of its biochemistry have not been definitively resolved. Recently, major advances have been made in P-glycoprotein biochemistry with the use of purified and reconstituted P-glycoprotein, as well as membranes from nonmammalian cells containing heterologously expressed P-glycoprotein. In this review we describe recent findings using these systems which are elucidating the molecular mechanism of P-glycoprotein-mediated drug transport.
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收藏
页码：7 / 13
页数：7
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