PENETRATION OF FUSIDIC ACID INTO HUMAN BRAIN-TISSUE AND CEREBROSPINAL-FLUID

被引：14

作者：

MINDERMANN, T

ZIMMERLI, W

RAJACIC, Z

GRATZL, O

机构：

[1] UNIV BASEL,KANTONSSPITAL,NEUROSURG KLIN,CH-4051 BASEL,SWITZERLAND

[2] UNIV BASEL,DEPT INNERE MED & FORSCH,INFEKTIOL ABT,CH-4051 BASEL,SWITZERLAND

来源：

ACTA NEUROCHIRURGICA | 1993年 / 121卷 / 1-2期

关键词：

FUSIDIC ACID; HUMAN BRAIN TISSUE; CEREBROSPINAL FLUID;

D O I：

10.1007/BF01405176

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Penetration of fusidic acid into brain tissue in six patients and cerebrospinal fluid in seven patients was determined. Tissue samples, taken during surgery revealed drug levels at about 7% of simultaneous serum concentrations. In contrast, cerebrospinal fluid concentrations were below 1% of serum levels. Since serum- and tissue levels of fusidic acid were far above the minimal inhibitory concentration (MICs) of staphylococci and streptococci, and since it has a long serum half-life of about 10 hours, it is a promising candidate for prophylaxis in neurosurgery.

引用

页码：12 / 14

页数：3

共 10 条

[1] ANTIBIOTIC SINGLE-DOSE PROPHYLAXIS OF SHUNT INFECTIONS [J].