GENETIC ASSOCIATION OF MATING TYPES AND VIRULENCE IN CRYPTOCOCCUS-NEOFORMANS

被引：358

作者：

KWONCHUNG, KJ

EDMAN, JC

WICKES, BL

机构：

[1] UNIV CALIF SAN FRANCISCO, HORMONE RES INST, SAN FRANCISCO, CA 94143 USA

[2] UNIV CALIF SAN FRANCISCO, DEPT LAB MED, SAN FRANCISCO, CA 94143 USA

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 02期

关键词：

D O I：

10.1128/IAI.60.2.602-605.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A pair of congenic Cryptococcus neoformans var. neoformans strains, B-4476 (a mating type) and B-4500 (alpha-mating type), that presumably differ only in mating type was constructed. This pair and their progeny, five alpha-type and five a type, were tested for virulence in mice. In the parent strains as well as the progeny, alpha-type was clearly more virulent than a type. In addition, death tended to occur earlier among the alpha-strain-infected mice that died than among the mice that died by infection caused by a strains. These data strongly suggest the genetic association of virulence with mating type in this human fungal pathogen.

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页码：602 / 605

页数：4

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