SPECTRIN BREAKDOWN PRODUCTS INCREASE WITH AGE IN TELENCEPHALON OF MOUSE-BRAIN

被引：27
作者：
BAHR, BA
VANDERKLISH, PW
HA, LT
TIN, MT
LYNCH, G
机构：
[1] Center for the Neurobiology of Learning and Memory, University of California, Irvine
来源：
NEUROSCIENCE LETTERS | 1991年 / 131卷 / 02期
关键词：
AGING; BRAIN; CALPAIN; SPECTRIN; CYTOSKELETON; NEUROPATHOLOGY;
D O I：
10.1016/0304-3940(91)90622-Z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Calcium activated proteolysis of brain spectrin produces characteristic breakdown products (BDPs), the concentrations of which increase markedly in many instances of brain pathology. Results reported here indicate that levels of the BDPs rise with age (3-30 months) in the telencephalon but not in the hindbrain of Balb/c mice. These observations suggest that spectrin breakdown is a pathologic biochemical marker which increases with age in some but not all brain regions.
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页码：237 / 240
页数：4
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