A PLASMA-MEMBRANE PROGESTERONE-RECEPTOR IN HUMAN SPERM IS SWITCHED ON BY INCREASING INTRACELLULAR FREE CALCIUM

被引：44

作者：

MENDOZA, C

TESARIK, J

机构：

[1] AMER HOSP PARIS,63 BLVD VICTOR HUGO,F-92202 NEUILLY SUR SEINE,FRANCE

[2] UNIV GRANADA,FAC SCI,DEPT BIOCHEM & MOLEC BIOL,E-18071 GRANADA,SPAIN

[3] INSERM,F-92140 CLAMART,FRANCE

来源：

FEBS LETTERS | 1993年 / 330卷 / 01期

关键词：

PROGESTERONE RECEPTOR; PLASMA MEMBRANE; NONGENOMIC STEROID EFFECTS; CALCIUM MOBILIZATION; HUMAN SPERM;

D O I：

10.1016/0014-5793(93)80919-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have revealed the presence of an atypical progesterone receptor on the plasma membrane of a relatively small subpopulation of human sperm cells. In this study, we show that the receptor is present in many cells in a latent form and that the receptor function in these cells is switched on asynchronously by increasing intracellular free Ca2+ levels. Under physiological conditions, this process occurs during sperm capacitation, but it can be mimicked by a short sperm exposure to the Ca2+-mobilizing agent thapsigargin. These observations suggest a role of Ca2+ as a modulator of nongenomic steroid effects on the cell surface.

引用

页码：57 / 60

页数：4

共 14 条

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