EFFICIENT, RACEMIZATION-FREE AMIDATION OF PROTECTED AMINO-ACIDS

被引：0

作者：

SOMLAI, C ^{[1
]}

SZOKAN, G ^{[1
]}

BALASPIRI, L ^{[1
]}

机构：

[1] EOTVOS LORAND UNIV, INST ORGAN CHEM, H-1117 BUDAPEST, HUNGARY

来源：

SYNTHESIS-STUTTGART | 1992年 / 03期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-tert-Butoxycarbonyl derivatives of L-leucine, S-benzyl-L-cysteine and N(tau)-(2,4-dinitrophenyl)-L-histidine were amidated with crystalline ammonium, methylammonium, and ethylammonium salts of 3-hydroxy-1,2,3-benzotriazin-4(3H)-one and N-hydroxysuccinimide to give the corresponding amino acid amides in good yield and with good optical purity.

引用

页码：285 / 287

页数：3

共 11 条

[1]

BODANSZKY M, 1982, INT J PEPT PROT RES, V20, P387

[2] A NEW METHOD FOR SYNTHESIS OF PEPTIDES - ACTIVATION OF CARBOXY GROUP WITH DICYCLOHEXYLCARBODIIMIDE AND 3-HYDROXY-4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINE [J].

KONIG, W ;

GEIGER, R .

CHEMISCHE BERICHTE-RECUEIL, 1970, 103 (07) :2034-&

[3]

KONIG W, 1985, JUN AK C GRAIN EIBS

[4]

KOVACS J, 1980, PEPTIDES, V2, P529

[5]

LOW M, 1984, PEPTIDES 1984, P267

[6]

SCHON I, 1987, ACTA CHIM HUNG, V124, P191

[7] APPLICATION OF MARFEY REAGENT IN RACEMIZATION STUDIES OF AMINO-ACIDS AND PEPTIDES [J].

SZOKAN, G ;

MEZO, G ;

HUDECZ, F .

JOURNAL OF CHROMATOGRAPHY, 1988, 444 :115-122

[8]

SZOKAN G, 1989, J LIQ CHROMATOGR, V12, P2855

[9]

THAMM P, 1974, HOUBEN WEYL, V15, P465

[10] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC MONITORING OF TRANSPEPTIDATION REACTIONS IN ANALOGS OF GONADOTROPIN-RELEASING HORMONE CONTAINING ASPARTIC-ACID DERIVATIVES IN POSITION 6 [J].

VADASZ, Z ;

SEPRODI, J ;

ERCHEGYI, J ;

TEPLAN, I ;

SCHON, I .

JOURNAL OF CHROMATOGRAPHY, 1989, 477 (02) :377-385

← 1 2 →