BICUCULLINE INDUCED SEIZURES IN INFANT RATS - ONTOGENY OF BEHAVIORAL AND ELECTROCORTICAL PHENOMENA

被引：43

作者：

BARAM, TZ ^{[1
]}

SNEAD, OC ^{[1
]}

机构：

[1] UNIV SO CALIF,DEPT NEUROL,LOS ANGELES,CA 90089

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1990年 / 57卷 / 02期

关键词：

BICUCULLINE; SEIZURE; ONTOGENY; RAT-GAMMA-AMINOBUTYRIC ACID; BRAIN DEVELOPMENT;

D O I：

10.1016/0165-3806(90)90055-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effects of bicuculline, a gamma-aminobutyric acid (GABA) antagonist, were investigated in 258 immature rats between the third and 22nd postnatal days. Behavioral and electrocorticographic events were correlated. Bicuculline induced both behavioral and electrographic seizures as early as the third postnatal day, an age when the CD50 for bicuculline was lowest, and therefore the sensitivity to it was the greatest. Bicuculline may thus be a suitable convulsant for epilepsy studies involving rats during the first postnatal week.

引用

页码：291 / 295

页数：5

共 26 条

[1] GLUCOSE CONSUMPTION IN CEREBRAL-CORTEX OF RAT DURING BICUCULLINE-INDUCED STATUS EPILEPTICUS [J].

BORGSTROM, L ;

CHAPMAN, AG ;

SIESJO, BK .

JOURNAL OF NEUROCHEMISTRY, 1976, 27 (04) :971-973

[2] VARIATION IN THRESHOLD AND PATTERN OF ELECTROSHOCK-INDUCED SEIZURES IN RATS DEPENDING ON SITE OF STIMULATION [J].

BROWNING, RA ;

NELSON, DK .

LIFE SCIENCES, 1985, 37 (23) :2205-2211

[3] THE SUSCEPTIBILITY OF RATS TO PILOCARPINE-INDUCED SEIZURES IS AGE-DEPENDENT [J].

CAVALHEIRO, EA ;

SILVA, DF ;

TURSKI, WA ;

CALDERAZZOFILHO, LS ;

BORTOLOTTO, ZA ;

TURSKI, L .

DEVELOPMENTAL BRAIN RESEARCH, 1987, 37 (1-2) :43-58

[4] NEUROCHEMICAL ASPECTS OF ONTOGENESIS OF GABANERGIC NEURONS IN RAT-BRAIN [J].

COYLE, JT ;

ENNA, SJ .

BRAIN RESEARCH, 1976, 111 (01) :119-133

[5]

COYLE JT, 1984, ACTA NEUROL SCAND, V69, P1

[6] EFFECTS OF BICUCULLINE-INDUCED SEIZURES ON BENZODIAZEPINE AND ADENOSINE RECEPTORS IN DEVELOPING RAT-BRAIN [J].

DAVAL, JL ;

SARFATI, A .

LIFE SCIENCES, 1987, 41 (14) :1685-1693

[7] BICUCULLINE-INDUCED AND ALLYLGLYCINE-INDUCED EPILEPSY IN DEVELOPING RATS [J].

DEFEO, MR ;

MECARELLI, O ;

RICCI, GF .

EXPERIMENTAL NEUROLOGY, 1985, 90 (02) :411-421

[8] CENTRAL GABA MECHANISMS DURING POSTNATAL-DEVELOPMENT IN THE RAT - NEUROCHEMICAL CHARACTERISTICS [J].

HEDNER, T ;

IVERSEN, K ;

LUNDBORG, P .

JOURNAL OF NEURAL TRANSMISSION, 1984, 59 (02) :105-118

[9] GAMMA-AMINOBUTYRIC-ACID OPENS CL-CHANNELS IN CULTURED ASTROCYTES [J].

KETTENMANN, H ;

BACKUS, KH ;

SCHACHNER, M .

BRAIN RESEARCH, 1987, 404 (1-2) :1-9

[10]

KNOWLES WD, 1989, CLEVELAND CLIN J M S, V56, P221

← 1 2 3 →