THE EFFECT OF HEPTAKIS (2,6-DI-O-METHYL)-GAMMA-CYCLODEXTRIN ON MITOMYCIN-C STABILITY IN AQUEOUS-SOLUTION

被引：2
|
作者：
SUENAGA, A
BEKERS, O
BEIJNEN, JH
UNDERBERG, WJM
TANIMOTO, T
KOIZUMI, K
OTAGIRI, M
机构：
[1] KUMAMOTO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT,5-1 OE HONMACHI,KUMAMOTO 862,JAPAN
[2] STATE UNIV UTRECHT,FAC PHARM,DEPT PHARMACEUT ANAL,3511 GH UTRECHT,NETHERLANDS
[3] SLOTERVAART HOSP,NETHERLANDS CANC INST,1066 EC AMSTERDAM,NETHERLANDS
[4] MUKOGAWA WOMENS UNIV,FAC PHARMACEUT SCI,NISHINOMIYA,HYOGO 663,JAPAN
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 59卷 / 02期
关键词：
Heptakis (2,3,6-tri-O-methyl)-γ-cyclodextrin; Heptakis (2,6-di-O-methyl)-γ-cyclodextrin; Inclusion complex; Mitomycin C degradation; Stabilization; γ-Cyclodextrin;
D O I：
10.1016/0378-5173(90)90086-J
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The inclusion of mitomycin C in γ-cyclodextrin and two of its methylated derivatives has been investigated as well as the effect of the process on the stability of the guest molecule. Inclusion of mitomycin C in heptakis (2,6-di-O-methyl)-γ-cyclodextrin has the greatest effect, whilst in γ-cyclodextrin it is less pronounced and in the case of heptakis (2,3,6-tri-O-methyl)-γ-cyclodextrin activity was undetectable. On complexation with cyclodextrins, the degradation of mitomycin C proceeds at a slower rate, in both acidic and alkaline media. The effect of heptakis (2,6-di-O-metnyl)-γ-cyclodextrin is also greater in this respect and is apparently correlated with the stability of the complex. Using CD and H NMR spectroscopy some insight has been gained into the structure of mitomycin C-cyclodextrin complexes. © 1990.
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页码：121 / 130
页数：10
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