METABOLIC AND HEMODYNAMIC-EFFECTS OF MAGNESIUM SUPPLEMENTATION IN PATIENTS WITH ESSENTIAL-HYPERTENSION

被引：48

作者：

ZEMEL, PC ^{[1
]}

ZEMEL, MB ^{[1
]}

URBERG, M ^{[1
]}

DOUGLAS, FL ^{[1
]}

GEISER, R ^{[1
]}

SOWERS, JR ^{[1
]}

机构：

[1] CIBA GEIGY CORP,DIV PHARMACEUT,SUMMIT,NJ 07901

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1990年 / 51卷 / 04期

关键词：

Blood pressure; Cation metabolism; Lipids; Magnesium;

D O I：

10.1093/ajcn/51.4.665

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effect of magnesium supplementation on blood pressure, erythrocyte cation metabolism, and serum lipids was evaluated in 13 patients with mild hypertension. After randomization and a 3-wk placebo run-in period, seven patients received 40 mmol Mg asparate (20 mmol elemental Mg twice daily) and six received placebo for 3 mo. In comparison with placebo treatment, magnesium aspartate therapy had no effect on blood pressure, lipid concentrations, or erythrocyte cation metabolism. These results demonstrate that in magnesium-repleted hypertensive subjects, magnesium supplementation does not affect blood pressure or lipids probably because magnesium has no effect on cellular cation metabolism in magnesium-replete individuals.

引用

页码：665 / 669

页数：5

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