METABOLIC AND HEMODYNAMIC-EFFECTS OF MAGNESIUM SUPPLEMENTATION IN PATIENTS WITH ESSENTIAL-HYPERTENSION

被引：48
|
作者：
ZEMEL, PC [1 ]
ZEMEL, MB [1 ]
URBERG, M [1 ]
DOUGLAS, FL [1 ]
GEISER, R [1 ]
SOWERS, JR [1 ]
机构：
[1] CIBA GEIGY CORP,DIV PHARMACEUT,SUMMIT,NJ 07901
来源：
AMERICAN JOURNAL OF CLINICAL NUTRITION | 1990年 / 51卷 / 04期
关键词：
Blood pressure; Cation metabolism; Lipids; Magnesium;
D O I：
10.1093/ajcn/51.4.665
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The effect of magnesium supplementation on blood pressure, erythrocyte cation metabolism, and serum lipids was evaluated in 13 patients with mild hypertension. After randomization and a 3-wk placebo run-in period, seven patients received 40 mmol Mg asparate (20 mmol elemental Mg twice daily) and six received placebo for 3 mo. In comparison with placebo treatment, magnesium aspartate therapy had no effect on blood pressure, lipid concentrations, or erythrocyte cation metabolism. These results demonstrate that in magnesium-repleted hypertensive subjects, magnesium supplementation does not affect blood pressure or lipids probably because magnesium has no effect on cellular cation metabolism in magnesium-replete individuals.
引用
收藏
页码：665 / 669
页数：5
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