FACTORS RELATED TO EARLY-PREGNANCY RECOGNITION IN THE WOMAN

被引：1
作者：
BEHR, B
STONE, B
FOOTE, WD
机构：
[1] Department of Biology, University of Nevada-Reno, Reno, 89504, Nevada
[2] Reproductive Technology Lab, California Fertility Associates, Santa Monica, California
来源：
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1995年 / 12卷 / 04期
关键词：
CORPUS LUTEUM; LUTEOTROPIN; PREGNANCY; ESTRADIOL;
D O I：
10.1007/BF02212932
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Purpose: While the precise timing of the maternal recognition of pregnancy is not known, it is known that the prevention of return to ovarian cyclicity relies on a conceptus-derived signal. Methods: In an attempt to identify the first luteotropic signals detectable in the maternal circulation, a sensitive Leydig cell luteotropin bioassay was employed, and data were compared for nine clinically pregnant and nine nonpregnant patients in an in vitro fertilization program, Blood samples were drawn every other day for 10 days after embryo transfer (ET). Results: The first detectable rise in bioactive luteotropin levels occurred between 6 and 8 days post ET. Serum E(2) levels increased on the same days. Differences in luteotropin levels between pregnant and nonpregnant patients were significant between days 6 and 8 (P < 0.0001) and between days 8 and 10 (P < 0.002). Conclusions: Based on morphological studies reported by others, bioactive luteotropic signals identified in this study were detectable in the maternal circulation at about the time of trophoblast lacunae coalescing with maternal uterine blood vessels.
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页码：278 / 282
页数：5
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