PROTECTIVE EFFECTS OF CIPROFLOXACIN AGAINST TYPE-II COLLAGEN INDUCED ARTHRITIS IN RATS

被引：0

作者：

BREBAN, M

FOURNIER, C

GOUGEROTPOCIDALO, MA

MUFFATJOLY, M

POCIDALO, JJ

机构：

[1] HOP CLAUDE BERNARD,INSERM,U13,190 BLVD MACDONALD,F-75019 PARIS,FRANCE

[2] HOP COCHIN,INSERM,U283,F-75674 PARIS 14,FRANCE

[3] HOP BICHAT,INSERM,U294,F-75877 PARIS 18,FRANCE

来源：

JOURNAL OF RHEUMATOLOGY | 1992年 / 19卷 / 02期

关键词：

CIPROFLOXACIN; COLLAGEN INDUCED ARTHRITIS; TNF; IL-1; ANTIGLUCOCORTICOID; ANTIINFLAMMATORY EFFECT;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ciprofloxacin, a new fluoroquinolone antibiotic, inhibits the in vitro production of interleukin 1-beta and tumor necrosis factor alpha by monocytes. We investigated its activity against type II collagen induced arthritis in rats. It exerted a dose dependent preventive effect at 50 and 75 mg/kg/day against clinical and histologic features of collagen induced arthritis without any influence on the production of anticollagen antibodies and alpha-1-acid glycoprotein. This effect was reversible after early removal of the treatment. Ciprofloxacin did not inhibit collagen induced arthritis in adrenalectomized rats but rather caused an exacerbation of the disease. Its effect was not modified by the simultaneous administration of an antiglucocorticoid, RU 40555.

引用

页码：216 / 222

页数：7

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[11] CACHECTIN TUMOR NECROSIS FACTOR STIMULATES COLLAGENASE AND PROSTAGLANDIN-E2 PRODUCTION BY HUMAN SYNOVIAL-CELLS AND DERMAL FIBROBLASTS [J].