KINETIC PREFERENCE OF 5'GMP OVER 3'GMP IN REACTIONS WITH PLATINUM AMINE COMPOUNDS AS STUDIED BY COMPETITION REACTIONS

被引：19

作者：

BLOEMINK, MJ ^{[1
]}

LEMPERS, ELM ^{[1
]}

REEDIJK, J ^{[1
]}

机构：

[1] LEIDEN STATE UNIV,GORLAEUS LABS,DEPT CHEM,POB 9502,2300 RA LEIDEN,NETHERLANDS

来源：

INORGANICA CHIMICA ACTA | 1990年 / 176卷 / 02期

关键词：

D O I：

10.1016/S0020-1693(00)84862-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Competitive binding of 5'GMP and 3'GMP with [PtCl(dien)]Cl has been performed as a function of pH. The identity and relative amounts of the reaction products have been determined by H-1 NMR spectroscopy. The ratio of the formed products, [Pt(dien)(5'GMP-N7)], increases from 3.5 at pH 4 to 7.5 at pH 9. An apparent pK(a) of 6.6 is observed which corresponds to a phosphate (de)hydronation. The kinetic preference for 5'GMP is caused by the position and the charge of the phosphate group.

引用

页码：317 / 320

页数：4

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