ENHANCEMENT OF HEART ALLOGRAFT SURVIVAL ACROSS H-2D DIFFERENCES

被引：5
作者：
DAVIS, WC
机构：
[1] Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA
来源：
TRANSPLANTATION | 1979年 / 28卷 / 05期
关键词：
D O I：
10.1097/00007890-197911000-00012
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The use of split heart allografts in the study of immunological enhancement was evaluated. The study revealed that, in contrast to the results with skin grafts, it is possible to obtain exceptional increases in the survival of heart grafts across differences at the H-2D end of the H-2 complex. The factors affecting graft survival were the age of the heart tissue used in grafting, the haplotype of the donor and host, the regimen of injections of antibody, and the immune reagent used. The data suggest that a difference exists in the mechanism by which anti-la and anti-H-2D antibodies mediate their enhancing effect. © 1979 by The Williams and Wilkins Co.
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收藏
页码：405 / 411
页数：7
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