INSULIN RESISTANCE IN WERNER SYNDROME

被引:9
作者
OKAMOTO, M [1 ]
OKAMOTO, M [1 ]
YAMADA, K [1 ]
YOSHIMASA, Y [1 ]
KOSAKI, A [1 ]
KONO, S [1 ]
INOUE, G [1 ]
MAEDA, I [1 ]
KUBOTA, M [1 ]
HAYASHI, T [1 ]
KATO, S [1 ]
KUZUYA, H [1 ]
IMURA, H [1 ]
机构
[1] KYOTO UNIV,SCH MED,DEPT MED,DIV 2,54 KAWAHARACHO,SAKYO KU,KYOTO 606,JAPAN
关键词
WERNER SYNDROME; INSULIN RESISTANCE; GLUCOSE CLAMP; AGING;
D O I
10.1016/0047-6374(92)90013-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Insulin resistance in Werner's syndrome (WS) was studied using the glucose clamp technique, and compared with physiologically aged and young subjects. Fasting immuno-reactive insulin (IRI) was increased in patients with Werner's syndrome compared with aged and young subjects. Metabolic clearance rate (MCR) of glucose was decreased in the aged and WS. A rightward shift of the dose-response curves of insulin and MCR of glucose was observed in the aged and WS with a more pronounced shift in the latter. MCR of insulin was also decreased in WS. [I-125]insulin binding to erythrocytes was similar in the three groups. These results suggest that insulin resistance associated with WS is due to a post-binding defect manifested by a rightward shift of the dose-response curve of insulin-induced glucose disposal and a decrease in insulin clearance rate.
引用
收藏
页码:11 / 25
页数:15
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