EFFECT OF FIBRINOGEN DEGRADATION PRODUCTS AND SOME LYSINE ANALOGS ON THE DISSOCIATION OF PLASMIN(OGEN)-FIBRIN COMPLEXES

被引：24
作者：
CEDERHOLMWILLIAMS, SA
SWAIN, A
机构：
[1] Department of Haematology, John Radcliffe Hospital, Oxford
来源：
THROMBOSIS RESEARCH | 1979年 / 16卷 / 5-6期
关键词：
6-AHA; complexes; dissociation; fibrin; fragment-E; Plasmin(ogen);
D O I：
10.1016/0049-3848(79)90214-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fibrin carries sites which bind plasmin and preactivated plasminogen (mol.wt. 84,000) allowing the formation of stable complexes. Fibrinogen degradation product E interferes with this complex formation suggesting that the plasmin(ogen) binding site is present in this fragment. The complexes are also dissociated by the anti-fibrinolytic agents 6-aminohexanoic acid and aminomethyl cyclohexanoic acid which both compete for the fibrin binding site of plasmin and plasminogen. © 1979.
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页码：705 / 713
页数：9
相关论文
共 18 条
[1]   ROLE OF UROKINASE AND TISSUE ACTIVATOR IN SUSTAINING BLEEDING AND MANAGEMENT THEREOF WITH EACA AND AMCA [J].
ANDERSSON, L ;
NILSOON, IM ;
COLLEEN, S ;
GRANSTRAND, B ;
MELANDER, B .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1968, 146 (A2) :642-+
[2]  
BLOMBACK B, 1957, ARK KEMI, V10, P415
[3]  
BROCKWAY WJ, 1971, J BIOL CHEM, V246, P4641
[4]   BINDING OF PLASMINOGEN (MOL WT 84,000) AND PLASMIN TO FIBRIN [J].
CEDERHOLMWILLIAMS, SA .
THROMBOSIS RESEARCH, 1977, 11 (03) :421-423
[5]   ALLOSTERIC EFFECTS OF SOME ANTI-FIBRINOLYTIC AMINO-ACIDS ON CATALYTIC ACTIVITY OF HUMAN PLASMIN [J].
CHRISTENSEN, U .
BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 526 (01) :194-201
[6]   PHYSICOCHEMICAL AND PROENZYME PROPERTIES OF NH2-TERMINAL GLUTAMIC-ACID AND NH2-TERMINAL LYSINE HUMAN PLASMINOGEN - INFLUENCE OF 6-AMINOHEXANOIC ACID [J].
CLAEYS, H ;
VERMYLEN, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 342 (02) :351-359
[7]   PLASMINOGEN - PURIFICATION FROM HUMAN PLASMA BY AFFINITY CHROMATOGRAPHY [J].
DEUTSCH, DG ;
MERTZ, ET .
SCIENCE, 1970, 170 (3962) :1095-+
[8]  
Doolittle R F, 1973, Adv Protein Chem, V27, P1, DOI 10.1016/S0065-3233(08)60446-5
[9]  
ENGEL PC, 1977, ENZYME KINETICS, P36
[10]   DETERMINATION OF PLASMINOGEN IN CLOTS AND THROMBI [J].
HEDNER, U ;
NILSSON, IM ;
ROBERTSO.B .
THROMBOSIS ET DIATHESIS HAEMORRHAGICA, 1966, 16 (1-2) :38-&
12