POOR RESPONSE OF BREAST-CANCER TO TAMOXIFEN

被引:10
作者
MCDONALD, PJ
CARPENTER, R
ROYLE, GT
TAYLOR, I
机构
[1] University Surgical Unit, F Level, Centre Block, Southampton General Hospital, Southampton, Tremona Road
关键词
D O I
10.1136/pgmj.66.782.1029
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fifty eight (58) patients with early breast cancer (mean age 78.3 years) and 37 patients with advanced breast cancer (mean age 65.9 years) were treated with tamoxifen orally 20 mg daily or twice daily. The mean follow-up time was 19.1 months in the early group and 18.4 months in the late group. The drug was extremely well tolerated. All patients had cytological or histological evidence of breast cancer. A complete or partial response was found in only 36% of the patients with early breast cancer and only 13% in the advanced group. We conclude that tamoxifen was disappointing as a primary therapy in our patients. Although because of its lack of toxicity it can be seen as initial therapy for patients with breast cancer, it may have to be supplanted rapidly by other forms of therapy in the substantial proportion of patients in whom a response will not occur.
引用
收藏
页码:1029 / 1031
页数:3
相关论文
共 11 条
[1]   TAMOXIFEN AS PRIMARY-TREATMENT OF BREAST-CANCER IN ELDERLY OR FRAIL PATIENTS - A PRACTICAL MANAGEMENT [J].
ALLAN, SG ;
RODGER, A ;
SMYTH, JF ;
LEONARD, RCF ;
CHETTY, U ;
PATRICK, A ;
FORREST, M .
BRITISH MEDICAL JOURNAL, 1985, 290 (6465) :358-358
[2]  
BRADBEER JW, 1983, CLIN ONCOL, V9, P31
[3]  
CAMPBELL FC, 1984, CLIN ONCOL, V10, P111
[4]  
GAZET JC, 1988, LANCET, V1, P679
[5]  
HAYWARD JL, 1977, CANCER, V39, P1289, DOI 10.1002/1097-0142(197703)39:3<1289::AID-CNCR2820390340>3.0.CO
[6]  
2-F
[7]  
PLOWMAN PN, 1988, LANCET, V1, P891
[8]   TAMOXIFEN AS INITIAL SOLE TREATMENT OF LOCALIZED BREAST-CANCER IN ELDERLY WOMEN - A PILOT-STUDY [J].
PREECE, PE ;
WOOD, RAB ;
MACKIE, CR ;
CUSCHIERI, A .
BRITISH MEDICAL JOURNAL, 1982, 284 (6319) :869-870
[9]  
RIBEIRO GG, 1984, CLIN ONCOL, V10, P363
[10]   COMPARISON OF MASTECTOMY WITH TAMOXIFEN FOR TREATING ELDERLY PATIENTS WITH OPERABLE BREAST-CANCER [J].
ROBERTSON, JFR ;
TODD, JH ;
ELLIS, IO ;
ELSTON, CW ;
BLAMEY, RW .
BRITISH MEDICAL JOURNAL, 1988, 297 (6647) :511-514