DIFFERENTIATION OF HUMAN NEURO-BLASTOMA CELLS IN CULTURE

被引：34
作者：
LITTAUER, UZ
GIOVANNI, MY
GLICK, MC
机构：
[1] UNIV PENN, SCH MED, DEPT PEDIAT, PHILADELPHIA, PA 19104 USA
[2] CHILDRENS HOSP, PHILADELPHIA, PA 19104 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0006-291X(79)91498-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Modulation of a membrane glycoprotein, approximate molecular weight 200,000, in concert with active ionic flux has been shown in a human neuroblastoma cell line. The modulating agent was 2% dimethyl sulfoxide. Other neuronal properties, acetylcholinesterase and choline acetyltransferase, were also modulated but to a lesser extent. The appearance of this glycoprotein on the surface of both human and mouse neuroblastoma cells only under conditions of differentiation leads to the suggestion that it is directly involved with the active Na+ channels. © 1979.
引用
收藏
页码：933 / 939
页数：7
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