Fatal Visceral Varicella-Zoster Developing Early after Autologous Hematopoietic Stem Cell Transplantation for Refractory Diffuse Large B-Cell Lymphoma

被引：0

作者：

Ichikawa, Satoshi ^{[1
,2
]}

Kim, Mihyun ^{[1
]}

Hasegawa, Shin ^{[1
]}

Ohashi, Keiichi ^{[1
]}

Kondo, Aiko ^{[1
]}

Kato, Hiroki ^{[1
]}

Kamata, Mayumi ^{[1
]}

Okitsu, Yoko ^{[1
]}

Fukuhara, Noriko ^{[1
]}

Onishi, Yasushi ^{[1
]}

Ishizawa, Kenichi ^{[1
]}

Harigae, Hideo ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Hematol & Rheumatol, Aoba Ku, 1-1 Seiryo Cho, Sendai, Miyagi 9808574, Japan

[2] Osaki Citizen Hosp, Dept Hematol, Osaki, Japan

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2014年 / 54卷 / 03期

关键词：

visceral zoster; inappropriate antidiuretic hormone secretion; autologous hematopoietic stem cell transplantation; diffuse large B-cell lymphoma;

D O I：

10.3960/jslrt.54.237

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A middle-aged woman who had undergone autologous hematopoietic stem cell transplantation (HSCT) 1 month previously suffered severe epigastralgia and relapse of lymphoma. The epigastralgia was not relieved by chemotherapy. Thereafter, her pancreatic and hepatic enzyme levels were markedly elevated and disseminated varicella emerged. Despite acyclovir administration, her general condition deteriorated rapidly and she died. Serum varicella zoster virus (VZV) DNA level was shown to be elevated and a diagnosis of disseminated VZV infection was established postmortem. In patients with severe abdominal pain following HSCT, early suspicion and therapeutic intervention for VZV are important, even in the absence of skin lesions.

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页码：237 / 241

页数：5

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