GENETIC-ANALYSIS OF THE RELATIONSHIPS BETWEEN BEHAVIORAL AND NEUROENDOCRINE TRAITS IN ROMAN HIGH-AVOIDANCE AND LOW-AVOIDANCE RAT LINES

被引：43

作者：

CASTANON, N

PEREZDIAZ, F

MORMEDE, P

机构：

[1] UNIV BORDEAUX 2, INRA,INSERM,CJF 9405, GENET STRESS & NEUROBIOL ADAPTAT LAB, F-33076 BORDEAUX, FRANCE

[2] UNIV PARIS 05, UFR BIOMED,GENET NEUROGENET & COMPORTEMENT LAB, CNRS,URA 1294, F-75270 PARIS 06, FRANCE

来源：

BEHAVIOR GENETICS | 1995年 / 25卷 / 04期

关键词：

ROMAN RAT LINES; ADRENAL HORMONES; PROLACTIN; AVOIDANCE BEHAVIOR; TYROSINE HYDROXYLASE AND PHENYLETHANOLAMINE N-METHYL TRANSFERASE ACTIVITIES; SEGREGATING CROSSES; MULTIVARIATE ANALYSIS;

D O I：

10.1007/BF02197288

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In order to determine whether the coselection observed between the selection trait (active avoidance behavior) of the Roman High Avoidance (RHA) and Roman Low Avoidance (RLA) rat lines and their neuroendocrine characteristics were genetically determined, we analyzed, in nonsegregating (RHA, RLA, and F-1) and segregating (F-2 and the two backcrosses) crosses, the inheritance pattern and the phenotypic correlations among behavioral (shuttle-box behavior), physiological (body, adrenal, and thymus weights), and neuroendocrine (corticosterone and prolactin reactivity, catecholamine enzyme activities) variables. Physiological characteristics and enzyme activities have a crucial role in sex dissociation. Avoidance behavior and prolactin reactivity to novel environment remained associated in segregating crosses despite gene rearrangement. They represented the most important variables to differentiate the Roman lines, perhaps sharing a common regulatory mechanism under genetic control.

引用

页码：371 / 384

页数：14

共 75 条

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