NEUTROPHIL FUNCTION AND PATHOLOGICAL FINDINGS IN HOLSTEIN CALVES WITH LEUKOCYTE ADHESION DEFICIENCY

被引:0
作者
NAGAHATA, H
KEHRLI, ME
MURATA, H
OKADA, H
NODA, H
KOCIBA, GJ
机构
[1] NATL INST ANIM HLTH, AOMORI 03925, JAPAN
[2] USDA, NATL ANIM DIS CTR, AMES, IA 50010 USA
[3] OHIO STATE UNIV, COLL VET MED, DEPT VET PATHOBIOL, COLUMBUS, OH 43210 USA
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D O I
暂无
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Leukocyte adhesion deficiency was diagnosed in 4 Holstein calves from 1 to 4 months old. Calves had severe ulcers on oral mucous membranes, gingivitis, severe periodontitis, chronic pneumonia, and stunted growth associated with severe neutrophilia. Neutrophils from affected calves had function defect, characterized by severely decreased adherence, chemotactic movements, phagocytosis, luminol-dependent chemiluminescent response, and O2--producing activities. Deficient CD18 expression (0.1 to 1.7%) on neutrophils was clearly detected by use of flow cytometric analysis. These affected calves were linked to a common ancestral sire that has been documented to be a carrier. Clinical features, leukocyte functional abnormalities, deficient expression of CD18, and mode of inheritance indicated that affected calves had leukocyte adhesion deficiency. In vitro leukocyte functional abnormalities were associated with deficiency in the expression of CD11/CD18. Pathologic findings indicated possible increased susceptibility to infection associated with this disease.
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页码:40 / 48
页数:9
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