IDDM - AN ISLET OR AN IMMUNE-DISEASE

被引：18

作者：

BOITARD, C ^{[1
]}

LARGER, E ^{[1
]}

TIMSIT, J ^{[1
]}

SEMPE, P ^{[1
]}

BACH, JF ^{[1
]}

机构：

[1] HOP BICHAT, SERV DIABETOL, F-75877 PARIS, FRANCE

来源：

DIABETOLOGIA | 1994年 / 37卷

关键词：

DIABETES MELLITUS; AUTOIMMUNITY; ANIMAL MODELS; AUTOANTIGENS; AUTOANTIBODIES; T CELLS;

D O I：

10.1007/BF00400831

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-dependent diabetes develops as a consequence of the selective destruction of insulin-producing cells by an autoimmune reaction. However, the precise series of events which trigger anti-islet autoreactive T cells is still being investigated. Major issues will need to be raised before a comprehensive view of the anti-islet autoimmune reaction can be delineated. These include defining the primary site of activation of autoreactive lymphocytes and exploring hypotheses to explain the chronicity of the diabetes process. These issues all relate with the more general dilemma of the actual role of the islets of Langerhans in breaking self tolerance to beta-cell antigens By studying non-obese diabetic mice deprived of beta cells following a single injection of a high dose of alloxan at 3 weeks of age, we recently obtained evidence that the activation of autoreactive T cells requires the presence of target islet cells in order to develop.

引用

页码：S90 / S98

页数：9

共 107 条

[91]

SIBLEY RK, 1985, LAB INVEST, V53, P132

[92] POLY-I-C INDUCES DEVELOPMENT OF DIABETES-MELLITUS IN BB RAT [J].