MOLECULAR-CLONING AND PRIMARY STRUCTURE OF A PROTEIN PHOSPHATASE-2C ISOFORM

被引：76

作者：

WENK, J ^{[1
]}

TROMPETER, HI ^{[1
]}

PETTRICH, KG ^{[1
]}

COHEN, PTW ^{[1
]}

CAMPBELL, DG ^{[1
]}

MIESKES, G ^{[1
]}

机构：

[1] UNIV DUNDEE,DEPT BIOCHEM,MRC,PROT PHOSPHORYLAT UNIT,DUNDEE DD1 4HN,SCOTLAND

来源：

FEBS LETTERS | 1992年 / 297卷 / 1-2期

关键词：

PROTEIN PHOSPHATASE; AMINO ACID SEQUENCE; ISOENZYME;

D O I：

10.1016/0014-5793(92)80344-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complementary DNA encoding the isoform of protein phosphatase 2C, termed PP2C2, has been isolated. The cDNA predicts a protein of 390 amino acid residues with a molecular mass of 42,888 Da. The protein displays 76% identity to the PP2C1 isoform.

引用

页码：135 / 138

页数：4

共 19 条

[1]

BARNES WM, 1987, METHOD ENZYMOL, V152, P538

[2] SCREENING GAMMAGT RECOMBINANT CLONES BY HYBRIDIZATION TO SINGLE PLAQUES INSITU [J].

BENTON, WD ;

DAVIS, RW .

SCIENCE, 1977, 196 (4286) :180-182

[3] INHIBITORY EFFECT OF A MARINE-SPONGE TOXIN, OKADAIC ACID, ON PROTEIN PHOSPHATASES - SPECIFICITY AND KINETICS [J].

BIALOJAN, C ;

TAKAI, A .

BIOCHEMICAL JOURNAL, 1988, 256 (01) :283-290

[4]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[5]

CLARKE PR, 1991, ADV PROT PHOSPHATASE, V6, P187

[6] THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES [J].

COHEN, P .

ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 :453-508

[7]

Davis L. G., 1986, BASIC METHODS MOL BI

[8] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

[9] EFFECTS OF THE TUMOR PROMOTER OKADAIC ACID ON INTRACELLULAR PROTEIN-PHOSPHORYLATION AND METABOLISM [J].

HAYSTEAD, TAJ ;

SIM, ATR ;

CARLING, D ;

HONNOR, RC ;

TSUKITANI, Y ;

COHEN, P ;

HARDIE, DG .

NATURE, 1989, 337 (6202) :78-81

[10] PROTEIN PHOSPHATASES - PROPERTIES AND ROLE IN CELLULAR-REGULATION [J].

INGEBRITSEN, TS ;

COHEN, P .

SCIENCE, 1983, 221 (4608) :331-338

← 1 2 →