MECHANISTIC STUDIES ON THE ASYMMETRIC ADDITION OF HCN TO ALDEHYDES CATALYZED BY CYCLO[(S)-HIS-(S)-PHE]

被引：17

作者：

HOGG, DJP ^{[1
]}

NORTH, M ^{[1
]}

机构：

[1] UNIV WALES,DEPT CHEM,BANGOR LL57 2UW,GWYNEDD,WALES

来源：

TETRAHEDRON | 1993年 / 49卷 / 05期

关键词：

CYCLO[(S)-PHENYLALANYL-(S)-HISTIDYL; CONFORMATION; HYDROCYANATION; ASYMMETRIC; MECHANISM;

D O I：

10.1016/S0040-4020(01)86289-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nature of the interaction between HCN and cyclol(S)-His-(S)-Phe] during the asymmetric hydrocyanation of benzaldehyde is investigated by variable pH nmr spectroscopy. The structure of the protonated form of cyclo[(S)-His-(S)-Phe] is determined by variable temperature NMR and molecular mechanics calculations.

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页码：1079 / 1090

页数：12

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