TELOMERES

被引：162

作者：

BLACKBURN, EH ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 10期

关键词：

D O I：

10.1016/0968-0004(91)90155-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres are specialized structures at the ends of eukaryotic linear chromosomes, consisting of protein-bound tandemly repeated simple DNA sequences. Telomeric DNA is unique in that it is copied from an RNA template that forms part of the enzyme, telomerase. This review discusses the synthesis and maintenance of these unusual structures.

引用

页码：378 / 381

页数：4

共 28 条

[1] CHROMOSOME ENDS IN DROSOPHILA WITHOUT TELOMERIC DNA-SEQUENCES [J].

BIESSMANN, H ;

CARTER, SB ;

MASON, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (05) :1758-1761

[2] TANDEMLY REPEATED SEQUENCE AT TERMINI OF EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES IN TETRAHYMENA [J].

BLACKBURN, EH ;

GALL, JG .

JOURNAL OF MOLECULAR BIOLOGY, 1978, 120 (01) :33-53

[3] THE MOLECULAR-STRUCTURE OF CENTROMERES AND TELOMERES [J].

BLACKBURN, EH ;

SZOSTAK, JW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1984, 53 :163-194

[4] STRUCTURE AND FUNCTION OF TELOMERES [J].

BLACKBURN, EH .

NATURE, 1991, 350 (6319) :569-573

[5]

BLACKBURN EH, 1990, SCIENCE, V249, P589

[6] RAP1 PROTEIN INTERACTS WITH YEAST TELOMERES INVIVO - OVERPRODUCTION ALTERS TELOMERE STRUCTURE AND DECREASES CHROMOSOME STABILITY [J].

CONRAD, MN ;

WRIGHT, JH ;

WOLF, AJ ;

ZAKIAN, VA .

CELL, 1990, 63 (04) :739-750

[7] TELOMERE PROTEINS - SPECIFIC RECOGNITION AND PROTECTION OF THE NATURAL TERMINI OF OXYTRICHA MACRONUCLEAR DNA [J].

GOTTSCHLING, DE ;

ZAKIAN, VA .

CELL, 1986, 47 (02) :195-205

[8] A TELOMERIC SEQUENCE IN THE RNA OF TETRAHYMENA TELOMERASE REQUIRED FOR TELOMERE REPEAT SYNTHESIS [J].

GREIDER, CW ;

BLACKBURN, EH .

NATURE, 1989, 337 (6205) :331-337

[9] THE TELOMERE TERMINAL TRANSFERASE OF TETRAHYMENA IS A RIBONUCLEOPROTEIN ENZYME WITH 2 KINDS OF PRIMER SPECIFICITY [J].

GREIDER, CW ;

BLACKBURN, EH .

CELL, 1987, 51 (06) :887-898

[10] AN OVERHANGING 3' TERMINUS IS A CONSERVED FEATURE OF TELOMERES [J].

HENDERSON, ER ;

BLACKBURN, EH .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (01) :345-348

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