Spectrophotometric Determination of Isoniazid in Dosage forms by Derivatization

被引：0
作者：
Rind, F. M. A. [1 ]
Khuhawar, M. Y. [2 ]
Almani, K. F. [1 ]
Rajpar, A. D. [3 ]
机构：
[1] Univ Sindh, Fac Pharm, Jamshoro, Pakistan
[2] Univ Sindh, Dr MA Kazi Inst Chem, Jamshoro, Pakistan
[3] Shah Abdul Latif Univ Khairpur, Dept Chem, Khairpur, Pakistan
来源：
PAKISTAN JOURNAL OF ANALYTICAL & ENVIRONMENTAL CHEMISTRY | 2005年 / 6卷 / 02期
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中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Isoniazid (INH) anti-tuberculosis drug was determined spectrophotometrically after derivatizing with 2-hydroxy-1,4-naphthoquinone (HNQ) at pH 3 in aqueous-methanolic solution. The reaction conditions were optimized and the derivative absorbed maximally at 365 nm. The Beer's law was obeyed in the range 5-25 mu g/ml. With coefficient of determination 0.9991. The method was applied for the determination of INH in pharmaceutical preparations with coefficient of variation 0.86-0.98.
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页码：84 / 88
页数：5
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