Spectrophotometric Determination of Isoniazid in Dosage forms by Derivatization

被引：0

作者：

Rind, F. M. A. ^{[1
]}

Khuhawar, M. Y. ^{[2
]}

Almani, K. F. ^{[1
]}

Rajpar, A. D. ^{[3
]}

机构：

[1] Univ Sindh, Fac Pharm, Jamshoro, Pakistan

[2] Univ Sindh, Dr MA Kazi Inst Chem, Jamshoro, Pakistan

[3] Shah Abdul Latif Univ Khairpur, Dept Chem, Khairpur, Pakistan

来源：

PAKISTAN JOURNAL OF ANALYTICAL & ENVIRONMENTAL CHEMISTRY | 2005年 / 6卷 / 02期

关键词：

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Isoniazid (INH) anti-tuberculosis drug was determined spectrophotometrically after derivatizing with 2-hydroxy-1,4-naphthoquinone (HNQ) at pH 3 in aqueous-methanolic solution. The reaction conditions were optimized and the derivative absorbed maximally at 365 nm. The Beer's law was obeyed in the range 5-25 mu g/ml. With coefficient of determination 0.9991. The method was applied for the determination of INH in pharmaceutical preparations with coefficient of variation 0.86-0.98.

引用

页码：84 / 88

页数：5

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