MECHANISM OF INHIBITION OF DNA GYRASE BY QUINOLONE ANTIBACTERIALS - A COOPERATIVE DRUG-DNA BINDING MODEL

被引:476
作者
SHEN, LL [1 ]
MITSCHER, LA [1 ]
SHARMA, PN [1 ]
ODONNELL, TJ [1 ]
CHU, DWT [1 ]
COOPER, CS [1 ]
ROSEN, T [1 ]
PERNET, AG [1 ]
机构
[1] UNIV KANSAS,DEPT MED CHEM,LAWRENCE,KS 66045
关键词
D O I
10.1021/bi00435a039
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:3886 / 3894
页数:9
相关论文
共 45 条
[1]   NALIDIXIC-ACID [J].
ACHARI, A ;
NEIDLE, S .
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1976, 32 (FEB15) :600-602
[2]   EVALUATION OF INTRINSIC BINDING-ENERGY FROM A HYDROGEN-BONDING GROUP IN AN ENZYME-INHIBITOR [J].
BARTLETT, PA ;
MARLOWE, CK .
SCIENCE, 1987, 235 (4788) :569-571
[3]   CALCULATION OF THE RELATIVE CHANGE IN BINDING FREE-ENERGY OF A PROTEIN-INHIBITOR COMPLEX [J].
BASH, PA ;
SINGH, UC ;
BROWN, FK ;
LANGRIDGE, R ;
KOLLMAN, PA .
SCIENCE, 1987, 235 (4788) :574-576
[4]   SIGN INVERSION MECHANISM FOR ENZYMATIC SUPERCOILING OF DNA [J].
BROWN, PO ;
COZZARELLI, NR .
SCIENCE, 1979, 206 (4422) :1081-1083
[5]  
CHAN PT, 1985, J BIOL CHEM, V260, P8925
[6]   SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIP OF 1-ARYL-6,8-DIFLUOROQUINOLONE ANTIBACTERIAL AGENTS [J].
CHU, DTW ;
FERNANDES, PB ;
MALECZKA, RE ;
NORDEEN, CW ;
PERNET, AG .
JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (03) :504-509
[7]   DNA GYRASE AND THE SUPERCOILING OF DNA [J].
COZZARELLI, NR .
SCIENCE, 1980, 207 (4434) :953-960
[8]   DNA GYRASE ON THE BACTERIAL CHROMOSOME - POSSIBILITY OF 2 LEVELS OF ACTION [J].
DRLICA, K ;
ENGLE, EC ;
MANES, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (11) :6879-6883
[9]   INHIBITORS OF DNA TOPOISOMERASES [J].
DRLICA, K ;
FRANCO, RJ .
BIOCHEMISTRY, 1988, 27 (07) :2253-2259
[10]  
FERNANDES PB, 1987, ANNU REP MED CHEM, V22, P117