EFFICACY OF THYROTROPIN-RELEASING-HORMONE IN THE TREATMENT OF SPINAL MUSCULAR-ATROPHY

被引：29

作者：

TAKEUCHI, Y ^{[1
]}

MIYANOMAE, Y ^{[1
]}

KOMATSU, H ^{[1
]}

OOMIZONO, Y ^{[1
]}

NISHIMURA, A ^{[1
]}

OKANO, S ^{[1
]}

NISHIKI, T ^{[1
]}

SAWADA, T ^{[1
]}

机构：

[1] KYOTO CITY CHILD WELF CTR,KYOTO,JAPAN

来源：

JOURNAL OF CHILD NEUROLOGY | 1994年 / 9卷 / 03期

关键词：

D O I：

10.1177/088307389400900313

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Children with spinal muscular atrophy were treated by the administration of thyrotropin-releasing hormone. In three infants with spinal muscular atrophy type I, thyrotropin-releasing hormone showed Little efficacy, but in children with types II and III, there was improvement in motor function and electromyographic findings after the thyrotropin-releasing hormone therapy. Thyrotropin-releasing hormone has a neurotrophic effect on the spinal anterior motor neurons of spinal muscular atrophy patients and thus may be warranted for the management of spinal muscular atrophy.

引用

页码：287 / 289

页数：3

共 12 条

[1]

BANDA R, 1985, Neurology, V35, P93

[2]

DUVOWITZ V, 1985, MUSCLE BIOPSY PRACTI, P254

[3] THYROTROPIN-RELEASING-HORMONE IN EXPERIMENTAL SPINAL-INJURY - DOSE-RESPONSE AND LATE TREATMENT [J].