A SILICON MICROMACHINED DEVICE FOR USE IN BLOOD-CELL DEFORMABILITY STUDIES

被引：34
作者：
TRACEY, MC [1 ]
GREENAWAY, RS [1 ]
DAS, A [1 ]
KAYE, PH [1 ]
BARNES, AJ [1 ]
机构：
[1] BARNET GEN HOSP,BARNET EN5 3DJ,HERTS,ENGLAND
来源：
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 1995年 / 42卷 / 08期
基金：
英国惠康基金;
关键词：
D O I：
10.1109/10.398635
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
An application of silicon micromachining to the analysis of blood cell theology is described. The system, based upon a micromachined flow cell, provides a specific measurement of each cell in a statistically significant population in terms of both flow velocity profile and an index of cell volume while the cells flow through an array of microchannels. The-rationale, design, and fabrication of the silicon micromachined flow cell is discussed. Interrelated considerations determining the design of the associated fluidic, mechanical, imaging, and real-time image analysis subsystems are examined. Sample data comparing normal and iron deficiency anaemic blood are presented to illustrate the potential of this technique.
引用
收藏
页码：751 / 761
页数：11
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