THE DISCOVERY OF A NOVEL CALCIUM-CHANNEL BLOCKER RELATED TO THE STRUCTURE OF POTASSIUM CHANNEL OPENER CROMAKALIM

被引：11
作者：
ATWAL, KS
MCCULLOUGH, JR
HEDBERG, A
CONDER, ML
AHMED, SZ
CUCINOTTA, G
NORMANDIN, DE
机构：
[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543-4000
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(00)80411-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
During our studies aimed at the identification of novel analogs of the potassium channel opener cromakalim (3), we serendipitously observed pyranoquinoline 4 to possess pure calcium channel blocking activity. The results of the studies conducted to confirm the calcium channel blocking mechanism of 4 are reported in this paper.
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页码：1475 / 1478
页数：4
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