SOLUBILITY AND ACID-BASE BEHAVIOR OF MIDAZOLAM IN MEDIA OF DIFFERENT PH, STUDIED BY ULTRAVIOLET SPECTROPHOTOMETRY WITH MULTICOMPONENT SOFTWARE

被引：38
作者：
ANDERSIN, R
机构：
[1] Pharmaceutical Chemistry Division, Department of Pharmacy, University of Helsinki, SF-00170 Helsinki
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1991年 / 9卷 / 06期
关键词：
MIDAZOLAM; HYDROLYSIS; STABILITY; UV SPECTROPHOTOMETRY; BENZOPHENONE IDENTIFICATION;
D O I：
10.1016/0731-7085(91)80246-6
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The solubility of midazolam is < 0.1 mg ml-1 at neutral pH and it increases considerably in acidic media. A pK(a) value of 6.04 at 24 +/- 1-degrees-C was calculated from the solubility data. In acidic media midazolam is reversibly converted to the corresponding benzophenone (open-ring form). The extent of this reaction was investigated by assaying the two compounds simultaneously by UV spectrophotometry with multicomponent software. The structure of the benzophenone derivative was verified by IR, MS and H-1 and C-13 NMR spectrometry.
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页码：451 / 455
页数：5
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