SYNTHESIS OF A BIOLOGICALLY-ACTIVE TAXOL ANALOG

被引：39
作者：
BLECHERT, S
KLEINEKLAUSING, A
机构：
[1] Institut für Organische Chemie, Technischen Universität, Berlin, W-1000
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 04期
关键词：
D O I：
10.1002/anie.199104121
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In an in vitro tubulin test, the depolymerization of tubulin was shown to be inhibited also by less functionalized taxol analogues such as 1. The alpha ring formation at C8 is achieved by a stereoselective de Mayo reaction of cyclohexene on a suitable functionalized 1,3-diketone.
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收藏
页码：412 / 414
页数：3
相关论文
共 12 条
  • [1] BLECHERT S, 1990, IN PRESS ALKALOIDS, V39
  • [2] GASKIN F, 1974, J MOL BIOL, V89, P73
  • [3] A SYNTHESIS OF TAXUSIN
    HOLTON, RA
    JUO, RR
    KIM, HB
    WILLIAMS, AD
    HARUSAWA, S
    LOWENTHAL, RE
    YOGAI, S
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (19) : 6558 - 6560
  • [4] SYNTHESIS OF A TAXANE TRIENE
    KENDE, AS
    JOHNSON, S
    SANFILIPPO, P
    HODGES, JC
    JUNGHEIM, LN
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (12) : 3513 - 3515
  • [5] NEW TAXANES FROM TAXUS-BREVIFOLIA
    KINGSTON, DGI
    HAWKINS, DR
    OVINGTON, L
    [J]. JOURNAL OF NATURAL PRODUCTS, 1982, 45 (04): : 466 - 470
  • [6] Lythgoe B., 1968, ALKALOIDS, V10, P597
  • [7] A BRIEF SURVEY OF TAXUS ALKALOIDS AND OTHER TAXANE DERIVATIVES
    MILLER, RW
    [J]. JOURNAL OF NATURAL PRODUCTS, 1980, 43 (04): : 425 - 437
  • [8] STEREOSELECTIVE SYNTHESIS OF TAXANE DERIVATIVES
    NEH, H
    KUHLING, A
    BLECHERT, S
    [J]. HELVETICA CHIMICA ACTA, 1989, 72 (01) : 101 - 109
  • [9] SENILH V, 1984, CR ACAD SCI II, V299, P1039
  • [10] SUFFNESS M, 1985, ALKALOIDS, V25, P6
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