SYNTHESIS OF A BIOLOGICALLY-ACTIVE TAXOL ANALOG

被引：39

作者：

BLECHERT, S

KLEINEKLAUSING, A

机构：

[1] Institut für Organische Chemie, Technischen Universität, Berlin, W-1000

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 04期

关键词：

D O I：

10.1002/anie.199104121

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In an in vitro tubulin test, the depolymerization of tubulin was shown to be inhibited also by less functionalized taxol analogues such as 1. The alpha ring formation at C8 is achieved by a stereoselective de Mayo reaction of cyclohexene on a suitable functionalized 1,3-diketone.

引用

页码：412 / 414

页数：3

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