EFFECT OF EXPERIMENTAL DIABETES ON THE CATECHOLAMINE METABOLISM IN RAT-BRAIN

被引：34

作者：

GUPTA, G ^{[1
]}

AZAM, M ^{[1
]}

BAQUER, NZ ^{[1
]}

机构：

[1] JAWAHARLAL NEHRU UNIV,SCH LIFE SCI,HORMONE & DRUG RES LAB,NEW DELH 110067,INDIA

来源：

JOURNAL OF NEUROCHEMISTRY | 1992年 / 58卷 / 01期

关键词：

CATECHOLAMINES; MONOAMINE OXIDASE; TYROSINE HYDROXYLASE; BRAIN; DIABETES; RAT;

D O I：

10.1111/j.1471-4159.1992.tb09282.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The levels of epinephrine, norepinephrine, and dopamine and the activities of tyrosine hydroxylase and monoamine oxidase were estimated in four regions of rat brain during alloxan-induced hyperglycemia and insulin-induced hypoglycemia. Catecholamine levels were estimated by HPLC, and the insulin levels were quantified by radioimmunoassay. The results demonstrated significant increases in the activities of the metabolizing enzymes and levels of catecholamines during experimental conditions. The levels of catecholamines were highest in the cerebral hemispheres, the region associated with high activities of the metabolizing enzymes. Insulin-induced hypoglycemia caused a decrease in the activities of the metabolizing enzymes followed by their recovery within 2 h.

引用

页码：95 / 100

页数：6

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