Efficacy and safety of lipid-lowering drugs in primary and secondary prevention of cardiovascular diseases in the elderly

被引：0
作者：
Ushkalova, E. A. [1 ]
Tkacheva, O. N. [2 ]
Runikhina, N. K. [2 ]
Chukhareva, N. A. [3 ]
Bevz, A. Yu. [2 ]
机构：
[1] Russian Univ Peoples Friendship, Mikluho Maclaya Ul 6, Moscow 6117198, Russia
[2] Russian Gerontol Res & Clin Ctr, Pervaya Leonova Ul 16, Moscow 129226, Russia
[3] Sci Ctr Obstet Gynecol & Perinatol, Oparina Ul 4, Moscow 117997, Russia
来源：
RATIONAL PHARMACOTHERAPY IN CARDIOLOGY | 2016年 / 12卷 / 03期
关键词：
the elderly; hypercholesterolemia; lipid-lowering therapy;
D O I：
10.20996/1819-6446-2016-12-3-351-358
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Effect of hyperlipidemia on morbidity and mortality in elderly patients is considered. Authors also cover issues of efficacy and safety of lipid-lowering therapy in primary and secondary prevention of cardiovascular diseases in patients >= 80 years of age who are the most quickly growing group of population and have the highest cardiovascular risk. They stress the need to take into account polymorbidity and polypharmacy that increase the risk of adverse reactions due to the use of both statins and their drug-drug interactions, which requires an assessment of risk/benefit ratio. In addition, there is a need for development of reliable prognostic tools to predict relevant outcomes (e.g., stroke, decrease in functionality/independence, quality of life reduction) and rationales for lipid-lowering therapy in the elderly and also their adherence to treatment.
引用
收藏
页码：351 / 358
页数：8
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