RESHAPING HUMAN-ANTIBODIES FOR THERAPY

被引：1140
作者：
RIECHMANN, L
CLARK, M
WALDMANN, H
WINTER, G
机构：
[1] MRC,MOLEC BIOL LAB,HILLS RD,CAMBRIDGE CB2 2QH,ENGLAND
[2] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND
来源：
NATURE | 1988年 / 332卷 / 6162期
关键词：
D O I：
10.1038/332323a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：323 / 327
页数：5
相关论文
共 46 条
[1]   TOLERANCE TO RAT MONOCLONAL-ANTIBODIES - IMPLICATIONS FOR SEROTHERAPY [J].
BENJAMIN, RJ ;
COBBOLD, SP ;
CLARK, MR ;
WALDMANN, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 163 (06) :1539-1552
[2]   PRODUCTION OF FUNCTIONAL CHIMAERIC MOUSE HUMAN-ANTIBODY [J].
BOULIANNE, GL ;
HOZUMI, N ;
SHULMAN, MJ .
NATURE, 1984, 312 (5995) :643-646
[3]   IMMUNOGLOBULIN HEAVY-CHAIN LOCUS OF THE RAT - STRIKING HOMOLOGY TO MOUSE ANTIBODY GENES [J].
BRUGGEMANN, M ;
FREE, J ;
DIAMOND, A ;
HOWARD, J ;
COBBOLD, S ;
WALDMANN, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (16) :6075-6079
[4]   COMPARISON OF THE EFFECTOR FUNCTIONS OF HUMAN-IMMUNOGLOBULINS USING A MATCHED SET OF CHIMERIC ANTIBODIES [J].
BRUGGEMANN, M ;
WILLIAMS, GT ;
BINDON, CI ;
CLARK, MR ;
WALKER, MR ;
JEFFERIS, R ;
WALDMANN, H ;
NEUBERGER, MS .
JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (05) :1351-1361
[5]  
Carson D A, 1986, Adv Immunol, V38, P275, DOI 10.1016/S0065-2776(08)60009-7
[6]   CANONICAL STRUCTURES FOR THE HYPERVARIABLE REGIONS OF IMMUNOGLOBULINS [J].
CHOTHIA, C ;
LESK, AM .
JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (04) :901-917
[7]   DOMAIN ASSOCIATION IN IMMUNOGLOBULIN MOLECULES - THE PACKING OF VARIABLE DOMAINS [J].
CHOTHIA, C ;
NOVOTNY, J ;
BRUCCOLERI, R ;
KARPLUS, M .
JOURNAL OF MOLECULAR BIOLOGY, 1985, 186 (03) :651-663
[8]  
CLARK MR, 1987, J NATL CANCER I, V79, P1393
[9]  
DELAND FH, 1982, RADIONUCLIDE IMAGING, P289
[10]  
EHRLICH P, 1957, IMMUNOLOGY CANCER RE, V2
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