STABILITY OF ITRACONAZOLE IN AN EXTEMPORANEOUSLY COMPOUNDED ORAL LIQUID

被引:6
作者
JACOBSON, PA
JOHNSON, CE
WALTERS, JR
机构
[1] UNIV MICHIGAN,COLL PHARM,ANN ARBOR,MI 48109
[2] UNIV MICHIGAN,MED CTR,ANN ARBOR,MI
关键词
ANTIFUNGALS; CAPSULES; COMPOUNDING; INCOMPATIBILITIES; ITRACONAZOLE; STABILITY; STORAGE; SUCROSE; SUSPENSIONS; SWEETENING AGENTS; TEMPERATURE;
D O I
10.1093/ajhp/52.2.189
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The stability of itraconazole in an extemporaneously compounded oral liquid formulation was studied. A suspension was prepared from the beads contained in commercially available 100 mg itraconazole capsules and sufficient Simple Syrup, NF, to make a final volume of 60 mt. The final concentration of itraconazole in the suspension was 40 mg/mL. Three identical volumes of each suspension were prepared and stored in 2-oz capped, amber glass prescription bottles and refrigerated at 4 degrees C (range, 2-6 degrees C). Immediately after preparation and at 7, 14, 21, 28, and 35 days, samples were visually inspected and assayed in duplicate by high-performance liquid chromatography; the pH of the samples was also determined. On day 35, the mean +/- S.D. percentage of initial itraconazole concentration remaining in the three suspensions was 95.3 +/- 2.2%. The color, odor, and pH of the samples did not change appreciably over the study period. Itraconazole 40 mg/mL in an oral liquid compounded from simple syrup and beads from capsules, stored in amber glass bottles, was stable for 35 days at 4 degrees C.
引用
收藏
页码:189 / 191
页数:3
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