VITAMIN-C IN CC14 HEPATOTOXICITY - A PRELIMINARY-REPORT

被引：15

作者：

ADEMUYIWA, O ^{[1
]}

ADESANYA, O ^{[1
]}

AJUWON, OR ^{[1
]}

机构：

[1] OGUN STATE UNIV,COLL HLTH SCI,DEPT BIOCHEM,AGO IWOYE,NIGERIA

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1994年 / 13卷 / 02期

关键词：

D O I：

10.1177/096032719401300208

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1 The hepatotoxic effect of CC14 was studied in the rat by using 3 well established liver function tests (plasma glucose, bilirubin and proteins) as indices of hepatic integrity. 2 The protective effect of vitamin C against this hepatotoxicity was also investigated. 3 CC14 (8 ml kg(-1) body weight) caused a decrease in the levels of plasma conjugated bilirubin, glucose and protein. 4 Vitamin C (2 g kg(-1) body weight) prevented liver damage induced by CC14. The possible mechanisms of protection are highlighted.

引用

页码：107 / 109

页数：3

共 17 条

[1] VITAMIN-E AND SELENIUM IN GENTAMICIN-NEPHROTOXICITY [J].

ADEMUYIWA, O ;

NGAHA, EO ;

UBAH, FO .

HUMAN & EXPERIMENTAL TOXICOLOGY, 1990, 9 (05) :281-288

[2] AN INCREASE IN GLUTATHIONE-PEROXIDASE ACTIVITY INDUCED BY HIGH SUPPLEMENTATION OF VITAMIN-C IN RATS [J].

CHEN, LH ;

THACKER, RR .

NUTRITION RESEARCH, 1984, 4 (04) :657-664

[3]

CHOJECKI Z, 1961, GASTROENTEROLOGY, V40, P521

[4] RESPONSE OF GLUTATHIONE PEROXIDASE TO DIETARY SELENIUM IN RATS [J].

CHOW, CK ;

TAPPEL, AL .

JOURNAL OF NUTRITION, 1974, 104 (04) :444-451

[5] STUDIES ON THE EFFECTS OF L-ASCORBIC-ACID ON ACETAMINOPHEN-INDUCED HEPATOTOXICITY .2. AN INVIVO ASSESSMENT IN MICE OF THE PROTECTION AFFORDED BY VARIOUS DOSAGE FORMS OF ASCORBATE [J].

HARGREAVES, RJ ;

EVANS, JG ;

PELLING, D ;

BUTTERWORTH, KR .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 64 (03) :380-392

[6]

Hinson JA., 1980, REV BIOCHEM TOXICOL, V2

[7]

MERCK E, 1970, MEDICO CHEM INVESTIG

[8] ASCORBIC-ACID DEFICIENCY AND HEPATIC UDP-GLUCURONYL TRANSFERASE - QUALITATIVE AND QUANTITATIVE DIFFERENCES [J].

NEUMANN, CM ;

ZANNONI, VG .

BIOCHEMICAL PHARMACOLOGY, 1990, 39 (06) :1085-1093

[9] DIRECT OBSERVATION OF A FREE-RADICAL INTERACTION BETWEEN VITAMIN-E AND VITAMIN-C [J].

PACKER, JE ;

SLATER, TF ;

WILLSON, RL .

NATURE, 1979, 278 (5706) :737-738

[10]

PLUMER DT, 1971, INTRO PRACTICAL BIOC

← 1 2 →