Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae)

被引：24

作者：

Eshwarappa, Ravi Shankara Birur ^{[1
,2
,3
]}

Ramachandra, Yarappa Lakshmikantha ^{[3
]}

Subaramaihha, Sundara Rajan ^{[2
]}

Subbaiah, Sujan Ganapathy Pasura ^{[2
]}

Austin, Richard Surendranath ^{[4
]}

Dhananjaya, Bhadrapura Lakkappa ^{[5
]}

机构：

[1] Jain Univ, Sch Grad Studies, Dept Chem, Bengaluru, Karnataka, India

[2] Jain Univ, Res Unit Vrukshayurveda, Bengaluru, Karnataka, India

[3] Kuvempu Univ, Dept Studies & Res Biotechnol, Shankarghatta, Karnataka, India

[4] Univ Mysore, Dept Biochem, Mysore, Karnataka, India

[5] Jain Univ, Ctr Emerging Technol, Dept Toxinol Toxicol & Drug Discovery, Ramanagara, Karnataka, India

来源：

PHARMACOGNOSY RESEARCH | 2016年 / 8卷 / 01期

关键词：

Antioxidant; Anti-lipoxygenase; Drug; Gallic acid; Galls; Plants; Terminalia chebula;

D O I：

10.4103/0974-8490.171103

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lipoxygenase (LOX) inhibitors are the promising therapeutic target for treating a wide spectrum of inflammatory-related diseases such as cancer, asthma, lymphoma, leukemia, and autoimmune disorders. In the present study, the photochemical constituents and the anti-LOX potential of leaf galls of Terminalia chebula are evaluated to exemplify its further potential development as medicine. Extracts of T. chebula galls were tested for anti-LOX activity using linoleic acid as substrate and lipoxidase as an enzyme and also the total content of polyphenols with phytochemical analysis of the extract were determined. The presence of highest total phenolic and flavonoid content of 141 +/- 2.2 mg of gallic acid equivalent/g d.w and 125 +/- 1.4 mg of quercetin equivalent/g d.w and maximal LOX inhibitory activity (52.67%) at 800 +/-g/mL concentrations were identified in the ethanolic extracts of leaf galls of T. chebula. The higher LOX inhibitory activity was positively correlated to the high content of total polyphenols/flavonoids. The results of this study confirm the folklore use of T. chebula leaves gall extracts as a natural anti-inflammatory agent and justify its ethnobotanical use. Therefore, the results encourage the use of T. chebula leave gall extracts for medicinal health, functional food, and nutraceuticals applications.

引用

页码：78 / 82

页数：5

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