IMMUNOREACTIVITY OF SKATE ELECTROCYTES TOWARDS MONOCLONAL-ANTIBODIES AGAINST HUMAN DYSTROPHIN AND DYSTROPHIN-RELATED (DMDL) PROTEIN

被引：1
|
作者：
DOWDALL, MJ [1 ]
ELLIS, JM [1 ]
MAN, NT [1 ]
MORRIS, GE [1 ]
机构：
[1] NE WALES INST,DIV RES,DEESIDE,CLWYD,WALES
来源：
NEUROSCIENCE LETTERS | 1992年 / 138卷 / 01期
关键词：
DYSTROPHIN; MONOCLONAL ANTIBODY; IMMUNOREACTIVITY; ELECTRIC ORGAN; ELECTROCYTE; SKATE; TORPEDO;
D O I：
10.1016/0304-3940(92)90464-I
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Monoclonal antibodies against human dystrophin have been used to demonstrate the existence of a dystrophin-like protein in the electrocytes of skate electric organ. This protein is also present in skate muscle and resembles that found in Torpedo electric organ. Monoclonal antibodies against a human autosomal homologue of dystrophin (DMDL protein) did not detect a similar protein in skate or Torpedo. Immunocytochemical staining of the innervated and non-innervated faces of the electrocyte membrane was obtained using the anti-dystrophin antibodies only.
引用
收藏
页码：27 / 31
页数：5
相关论文
共 50 条
  • [1] ASYMMETRIC DISTRIBUTION OF IMMUNOREACTIVITY AGAINST HUMAN DYSTROPHIN IN ELECTROCYTES OF RAJA-CLAVATA
    DOWDALL, MJ
    MORRELL, KJ
    JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S100 - S100
  • [2] MONOCLONAL-ANTIBODIES AGAINST DEFINED REGIONS OF THE MUSCULAR-DYSTROPHY PROTEIN, DYSTROPHIN
    MAN, NT
    CARTWRIGHT, AJ
    MORRIS, GE
    LOVE, DR
    BLOOMFIELD, JF
    DAVIES, KE
    FEBS LETTERS, 1990, 262 (02) : 237 - 240
  • [3] MONOCLONAL-ANTIBODIES TARGETED AGAINST THE C-TERMINAL DOMAIN OF DYSTROPHIN OR UTROPHIN
    FABBRIZIO, E
    LEGER, J
    ANOAL, M
    LEGER, JJ
    MORNET, D
    FEBS LETTERS, 1993, 322 (01) : 10 - 14
  • [4] DYSTROPHIN-RELATED PROTEIN, UTROPHIN, IN NORMAL AND DYSTROPHIC HUMAN FETAL SKELETAL-MUSCLE
    CLERK, A
    MORRIS, GE
    DUBOWITZ, V
    DAVIES, KE
    SEWRY, CA
    HISTOCHEMICAL JOURNAL, 1993, 25 (08): : 554 - 561
  • [5] LOCALIZATION OF THE DMDL GENE-ENCODED DYSTROPHIN-RELATED PROTEIN USING A PANEL OF 19 MONOCLONAL-ANTIBODIES - PRESENCE AT NEUROMUSCULAR-JUNCTIONS, IN THE SARCOLEMMA OF DYSTROPHIC SKELETAL-MUSCLE, IN VASCULAR AND OTHER SMOOTH MUSCLES, AND IN PROLIFERATING BRAIN-CELL LINES
    MAN, NT
    ELLIS, JM
    LOVE, DR
    DAVIES, KE
    GATTER, KC
    DICKSON, G
    MORRIS, GE
    JOURNAL OF CELL BIOLOGY, 1991, 115 (06): : 1695 - 1700
  • [6] LOCALIZATION AND QUANTITATION OF THE CHROMOSOME 6-ENCODED DYSTROPHIN-RELATED PROTEIN IN NORMAL AND PATHOLOGICAL HUMAN MUSCLE
    KARPATI, G
    CARPENTER, S
    MORRIS, GE
    DAVIES, KE
    GUERIN, C
    HOLLAND, P
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1993, 52 (02): : 119 - 128
  • [7] SPECIFICITY AND V-H SEQUENCE OF 2 MONOCLONAL-ANTIBODIES AGAINST THE N-TERMINUS OF DYSTROPHIN
    MORRIS, GE
    NGUYEN, C
    MAN, NT
    BIOCHEMICAL JOURNAL, 1995, 309 : 355 - 359
  • [8] LOCALIZATION AND QUANTITATION OF THE CHROMOSOME-6-ENCODED DYSTROPHIN-RELATED PROTEIN (UTROPHIN) IN PATHOLOGICAL HUMAN MUSCLE
    KARPATI, G
    CARPENTER, S
    GUERIN, C
    HOLLAND, P
    NEUROLOGY, 1993, 43 (04) : A294 - A295
  • [9] MONOCLONAL-ANTIBODIES AGAINST THE MUSCLE-SPECIFIC N-TERMINUS OF DYSTROPHIN - CHARACTERIZATION OF DYSTROPHIN IN A MUSCULAR-DYSTROPHY PATIENT WITH A FRAMESHIFT DELETION OF EXONS-3-7
    THANH, LT
    MAN, NT
    LOVE, DR
    HELLIWELL, TR
    DAVIES, KE
    MORRIS, GE
    AMERICAN JOURNAL OF HUMAN GENETICS, 1993, 53 (01) : 131 - 139
  • [10] THE DYSTROPHIN-RELATED PROTEIN, UTROPHIN, IS EXPRESSED ON THE SARCOLEMMA OF REGENERATING HUMAN SKELETAL-MUSCLE FIBERS IN DYSTROPHIES AND INFLAMMATORY MYOPATHIES
    HELLIWELL, TR
    MAN, NT
    MORRIS, GE
    DAVIES, KE
    NEUROMUSCULAR DISORDERS, 1992, 2 (03) : 177 - 184
12345